Helixomer is excited to share a breakthrough that could transform anticoagulant therapies and enhance patient care. Our research introduces RNA origami decorated with aptamers to create a safer, more controlled anticoagulant. Paired with a specific DNA reversal agent, this system functions act an on/off switch, allowing for precise coagulation control whenever needed. Together, our anticoagulant and reversal system offers a promising solution for safer blood thinners with minimized side effects and enhanced therapeutic control, marking a new era in thrombotic disease treatment and surgical care.  

Get the publication here: Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents, Adv. Healthc. Mat., 2021, 11, 2001826  DOI: 10.1002/adhm.202001826